Kamis, 25 April 2019 12:20

TEKNOLOGI

 / KEDOKTERAN & MEDIS

Has a second person with HIV been cured

  • Sugih
  • 06 Maret 2019 22:08
  • 0


Timothy Ray Brown, aka the “Berlin patient,” the only person to be cured of HIV, may finally have company. A decade after Brown became famous thanks to a stem cell transplant that eliminated his HIV infection, a similar transplant from a donor who has HIV-resistant cells appears to have cured another man, dubbed the “London patient.”

“This is a big deal,” says Sharon Lewin, who heads the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia. “It tells us that Timothy Brown wasn’t a one-off.” Although the interventions that  the two patients received could only be used on a tiny fraction of the 37 million HIV-infected people worldwide, their stories point to cure strategies that could be more widely applicable.



To treat blood cancers, both HIV-infected men received stem cell transplants from people who carried a mutation in the gene for CCR5, a cell surface molecule that many HIV strains use to infect cells. Beforehand, each had been treated with toxic chemicals in a “conditioning” regimen meant to kill off their existing cancerous
bone marrow cells. After HIV-resistant blood cells derived from the transplant supplanted the recipients’ vulnerable cells, the two patients stopped taking the antiretroviral (ARV) drugs that had been damping down their infections.



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